Biology
Kim PouliotAssistant Professor
Biography
Joined 91ÌÒÉ« in 2016.
Education
- B.A., Framingham State University
- Ph.D., University of Massachusetts Medical School, Worcester, MA
- Department of Microbiology and Molecular Genetics
Areas of Research
Dr. Pouliot is a classically trained microbiologist whose specializes in host-microbe interactions with a focus on the innate immune response. Previous research aided in the development of vaccines for the prevention HIV (UMASS) and Staphylococcus (Harvard Medical School/Brigham and Women's Hospital). The gp120-based (HIV) DNA vaccine will be entering Phase I Clinical trials later this year. Later, while working in industry, her preclinical work helped to develop a treatment for oral mucositis; A treatment that will also be entering preclinical trials this year.
Publications
Marty-Roix R., Vladimer G.I., Pouliot K., Weng D., , Buglione-Corbett R., West K., MacMicking J., Chee J., Wang S., Lu S., Lien E. Identification of QS-21 as an Inflammasome-Activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016 Vol.3
Pouliot K., Buglione-Corbett R., Marty-Roix R., Montminy-Paquette S., West K., Wang S., Lu S., Lien E. Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine. Vaccine 2014 Vol. 32.
Weng D., Marty-Roix R., Ganesan S., Proulx MK, Vladimer G., Kaiser WJ., Mocarski ES., Pouliot K., Chan F., Kelliher MA., Harris PA., Bertin J., Gough PJ, Shayakhmetov DM, Goguen JD., Fitzgerald KA, Silverman N., Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. PNAS 2014 Vol. 111.
Buglione-Corbett R., Pouliot K., Marty-Roix R., Li W., West K., Wang S., Morelli A., Lien E, Lu S. MyD88 dependency of ISCOMATRIXâ„¢ adjuvant effects is greatly reduced with DNA priming immunizations. Human Vaccines and Immunotherapeutics 2014 Vol. 10.
Buglione-Corbett R., Pouliot K., Marty-Roix R., West K., Wang S., Lien E, Lu S. Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy. PLoS One 2013 Vol. 8.
Watkins B., Pouliot K., Fey E., Tuthill C., Sonis S. Attenuation of radiation- and chemo-radiation induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Vol. 16.
Pouliot K., Pan, N., Wang S., Lu, S., Lien, E., Goguen JD. Evaluation of the role of LcrV/TLR2-mediated immunomodulation in the virulence of Yersinia pestis. Infect Immun 2007 Vol. 75
